The music mogul mentored 19-year-old Melanie Amaro to victory on the show's first season earlier this month, thereby automatically guaranteeing her a $5 million recording contract.
However, Cowell has since said that runner-up Josh Krajcik and third-placed contestant Chris Rene will most likely also be signed to the label, as will fellow Top 12 finalist Brian 'Astro' Bradley, who left the competition in seventh place.
Cowell explained the process of signing the acts in an interview with The Hollywood Reporter, explaining: "Anyone we're genuinely not interested in, they'll be let go. There is a lot of interest in a lot of the artists.
"We can't sign everyone, but there's going to be quite a few that are going to get deals. You're not going to let Astro go. You're not going to let Chris [Rene] go [or] let Josh go. We'd be mad. But she [Melanie Amaro] is the priority."
Cowell's Syco Music company - which all X Factor contestants are contractually bound to - has a deal with Sony Music, which includes the Epic, Columbia and RCA labels, with the acts able to sign to any label within the group.
Cowell recently promised that The X Factor USA will be "a bloodbath" during its second season and offer more exciting elements to the singing competition.
> Paula Abdul, LA Reid want X Factor USA return
Watch Simon Cowell discussing the future of the X Factor finalists with The Hollywood Reporter below: