Open casting calls will kick off at the Kemper Arena in Kansas City on March 14 before travelling to the Frank Erwin Centre in Austin (March 22), the Cow Palace in San Francisco (April 20) and the Greensboro Coliseum in Greensboro (May 1).
One further audition city will be announced at a later date.
> Read Digital Spy's full X Factor headlines
Once again, auditions are open to all solo artists and groups from the age of 12 upwards, and a new rule this season means hopefuls with a pre-existing management contract (subject to limited restrictions) are also eligible to try out.
Simon Cowell said in a statement: "We wanted to change a few things this year, so starting with the auditions, we've torn up the rulebook again. Even if you have management you can still enter, and we are making it easier by extending the online auditions and taking the MyStudio booths to even more cities.
"You can enter as many times as you want and come to any of the cities, too. We're here to discover stars from all music styles including groups. I really believe a group can win this show!"
This year's prize is a $5 million recording contract with Sony Music.
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Hopefuls unable to attend one of the open casting calls can submit an online audition consisting of a one-minute introduction and two-minute a cappella performance from March 1 at www.thexfactorusa.com.
They can also visit one of the MyStudio HD Recording Studios at various cities across the country from the dates below (with further locations to be announced later):
- New Jersey, Westfield Garden State Plaza - March 1
- Phoenix, Arizona Mills Mall - March 1
- Nashville, Coolsprings Centre Mall - March 1
- Honolulu - Pearlridge Centre - March 1
- Los Angeles, Westfield Culver City - March 9
- New England, Boxwoods Resort Casino - March 9
- Las Vegas, Planet Hollywood Resort - March 14
Reid said: "In the music industry, when you're looking for new talent you can discover it anywhere. The X Factor is opening this up to go further than anyone has before, and that's what it takes, so I can't wait to see what amazing talent we might find.
"I urge people to go out and audition, this is the real deal."
Melanie Amaro won the first season of The X Factor in December 2011, taking home the $5 million recording contract prize and the chance to star in a Pepsi Super Bowl commercial, which aired this month and featured Sir Elton John.
For full audition details visit www.thexfactorusa.com.
Watch Melanie Amaro's Super Bowl commercial below: