The music mogul told reporters on a conference call today (February 22) that he wants to bring in one man and one woman to share hosting duties when the show returns on Fox later this year.
He said: "It will be two. What we've learned on the show is you have so much information you have to relay as one person that I think it's almost impossible to have one person doing the hosting job. You have to give out so much information from phonelines to integration of the sponsors; they are like newscasters now, it's a much bigger role.
"I think there is a more fun way of doing it with two people, they can be in different parts of the studio throughout the show. I think you'll see a very different chemistry with two people. I always wanted a boy and girl to host the show and I think that will happen now."
Cowell also said that the possible new hosts might not come from a hosting background.
He added: "It's time for a change. We've been doing these shows for 11 years and you can't keep doing the same thing. I think we learned a lesson last year that the traditional host role on a show like this has to change into something else.
"The show will look different and feel different and I do think it's important, even though I'm talking myself out of a job here, that we have more Americans on the show."
The X Factor's first season was hosted by Welsh presenter Steve Jones, although it was confirmed earlier this year that he would not be returning for the second season.
Jones had initially been hired to co-host alongside Nicole Scherzinger but he became the sole host when she replaced Cheryl Cole as one of the four judges.
Open auditions for the second season of The X Factor kick off at the Kemper Arena in Kansas City on March 14 before travelling to the Frank Erwin Centre in Austin (March 22), the Cow Palace in San Francisco (April 20) and the Greensboro Coliseum in Greensboro (May 1).
Hopefuls can also audition via MyStudio Recording Booths and by submitting a tape online.
Full audition details are available at www.thexfactorusa.com.