The former Saved by the Bell actor was named as one of the show's presenters alongside Khloe Kardashian earlier this week.
He has now told HollywoodLife that he is excited about working with his co-star, who he described as his "favourite" Kardashian.
"I've known Khloe a long time, she's a sweetheart," he said. "I get along great with her and her family.
"She's got a great personality. I think she's ready for it."
Lopez, who claimed that Simon Cowell is his favourite judge, also described working on The X Factor USA as his "dream job", saying: "I am a big fan!"
Lopez and Kardashian will first appear on The X Factor USA with the opening live show, which airs November 1 on Fox.
Meanwhile, Lopez recently confirmed that his upcoming wedding to Courtney Mazza will be televised on TLC in December.