The series stars Sam Huntington, Sam Witwer and Meaghan Rath as a werewolf, a vampire and a ghost, who live together while trying to cope with their supernatural personas.
According to Deadline, Berkeley will star in an eight-episode run, where he will play a man hell-bent on wiping out vampires after the strange disappearance of his children.
Berkeley is best known for his roles as George Mason on 24 and Percy on the spy drama Nikita.
The US/Canadian version of Being Human was picked up for a third season by SyFy after stellar ratings this past fall.
A fifth run of the UK's Being Human is planned starring Damien Molony, Michael Socha and Kate Bracken.