The actor is nominated in this year's Awards for his performance as Don Draper and will compete against the likes of Boardwalk Empire's Steve Buscemi and House's Hugh Laurie.
Hamm told the Los Angeles Times: "If you're doing what we do just to win awards, you're focused on the wrong thing."
The category of 'Outstanding Lead Actor In A Drama Series' has been won by Breaking Bad star Bryan Cranston for the past three years, but he is not eligible for the 2011 Emmys.
Discussing the change, Hamm said: "The short answer to whether there's an advantage because [Cranston] isn't there is 'Yes'. [It's different] simply because he's not there. So someone else has to win."
Hamm previously revealed that he is "beyond thrilled" with the success of Mad Men at this year's Emmy nominations.
The 2011 Emmy Awards will take place on Sunday, September 18, while Mad Men will return to AMC for a fifth season in 2012.
> Mad Men creator 'didn't expect Emmy nods'
Watch a clip of Jon Hamm's performance in Mad Men episode 'The Suitcase' below: