The Modern Family actor will play a killer in the new season, which will premiere on Wednesday, October 17 at 10pm ET, reports TVLine.
Stonestreet previously appeared in the first season of the FX drama as a psych patient named Derek.
He won the 'Outstanding Supporting Actor in a Comedy Series' award at Sunday evening's Primetime Emmys for his role on Modern Family, while his co-star Julie Bowen took home the award for 'Outstanding Supporting Actress in a Comedy Series'.
Stonestreet is also making headlines for his personal life as he was reported to be dating Charlize Theron, but he denied the reports on his Twitter page.
"I wish people would stop spreading rumours that Charlize Theron and I are dating," he posted. "It's starting to make Halle Berry jealous."
Stonestreet broke up with his long-time girlfriend Katherine Tokarz "a couple of months ago".
Watch a clip of Eric Stonestreet on Modern Family below:
Photo gallery - Emmy 2012 winners: