The ABC series, which launches this September, is based during the early 1960s and follows the famous Pan Am stewardesses on their travels around the world.
However, Schlamme has dismissed the inevitable comparisons between the two shows and insisted that there are few similarities.
"Television is just execution," he said, according to The Hollywood Reporter. "It's not the time period it takes place in, it's not the characters. It has nothing to do with Mad Men."
It was also confirmed that the show will slowly introduce darker elements, such as the espionage subplot shown in the pilot episode.
"The espionage aspect is part of Kelli [Garner's] character," creator Jack Orman explained. "On a show that can go anywhere, it's an aspect. We weave it in pretty effectively so it isn't just its own storyline."
It was also confirmed that despite the time period none of the main characters will be seen smoking, with Schlamme explaining that it's the one "revisionist cheat" enforced on the show.
Pan Am features an ensemble cast including Christina Ricci, Margot Robbie, Mike Vogel and Kelli Garner.
The series will launch on September 25 on ABC in the US and on BBC Two in the UK later this year.
Watch the trailer for ABC's Pan Am below: