The show's executive producer Vince Gilligan also suggested that the relationship between the couple will begin to evolve.
"Oddly enough, as [Walt's] professional life gets darker, he and Skyler will come to some sort of an understanding," Gilligan told Entertainment Weekly.
"We'll see them partnered in a business, which will bring them together - and also cause a lot of friction. And the way they procure this business is a lot of fun."
Gilligan added: "It's interesting that Walt has long felt that what he does, he does for his family, and in that sense he and Skyler share a trait. We will grow to if not agree with many of her choices this season, respect her more this season for her mental toughness and pragmatism and desire to do right by her family."
Meanwhile, Cranston revealed that Skyler (Anna Gunn) will begin to see Walt in a new light.
"Skyler sees capabilities in [Walt] that she's never realised, and it changes her outlook," he explained. "For the first time, she's seeing her husband as a dangerous man - an intimidating, powerful man. And she gets involved, and she gets some very good ideas and surprising ideas to Walt. So they become closer in at least one way."
Gilligan has said that the new season of Breaking Bad will involve "twists and turns", while Cranston and his co-star Aaron Paul have described the season finale as "shocking".
Breaking Bad will return for its fourth season on July 17 on AMC.
Watch a trailer for the new season of Breaking Bad below (US only):