The drama will follow Cassie (Britt Robertson), a young girl who moves to Salem and discovers that she is a witch.
Heroes actress Crow will play Cassie's grandmother Jane Blake, according to Zap2it.
Her recent television credits include guest roles on Grey's Anatomy, In Plain Sight and The Mentalist.
She has also appeared in such films as 2002's Minority Report and 1993's The Good Son.
Natasha Henstridge, Louis Hunter, Thomas Dekker, Phoebe Tonkin, Gale Harold, Shelley Hennig and Jessica Parker Kennedy have all signed up to star in Secret Circle.
The pilot will be executive produced by The Vampire Diaries showrunner Kevin Williamson.
> Check out Digital Spy's pick of this year's pilots