The 46-year-old released a statement today giving his approval to Kutcher's recent casting as Charlie Sheen's replacement in the hit CBS sitcom.
He said: "I'm jazzed about the news this morning that Two and a Half Men is coming back! For all the rest of the cast and crew I'm sure they are equally excited... Ashton is an extraordinarily talented guy and his presence will be an asset to our show."
He further joked: "We are old friends from our male modelling days and we're both looking forward to being judged for our comedic artistry, as opposed to our exceptional physical beauty."
As well as applauding the new-look show, Cryer also paid tribute to his former colleague Sheen and stated that he was "extremely proud" of their work on Men.
He said: "I want to express my enormous gratitude to Charlie Sheen for eight great seasons. I'm extremely proud of the work we've done together and I will miss him. But I'm also looking forward to this new beginning."
Sheen was fired from Two and a Half Men in March after publicly blasting creator Chuck Lorre and a number of producers.
Sheen branded a Cryer a "traitor" for failing to speak out on his dismissal, but later issued a "half apology" to the actor for his comments.
Cryer previously described working with Sheen on Two and a Half Men as "a little weird".