According to The Hollywood Reporter, Aronsohn will move into an "executive consultant" position on the CBS sitcom next season.
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Writer-producers Don Reo and Jim Patterson are expected to be promoted to co-showrunners, alongside series creator Chuck Lorre.
Two and a Half Men has yet to be renewed for a tenth season, though it was recently suggested that stars Ashton Kutcher and Jon Cryer are nearing a new deal with the network.
Aronsohn recently drew controversy after he claimed during a screenwriting conference that TV had become too female-centric.
Earlier this month, Two and a Half Men hit a series low in Monday night ratings, though it picked up again this week.