It was rumoured that Cyrus was joining the show, but her representatives and CBS didn't comment on the reports when the news broke earlier this month.
Cyrus is now appearing in two episodes where she will portray Missi, "an old family friend of Walden's (Ashton Kutcher) who comes to visit for a week and develops a relationship with Jake (Angus T Jones) when he comes home from the army," reports Deadline.
She was also reportedly in talks to join American Idol's judging panel, but it was revealed she was "never seriously considered".
Cyrus recently debuted a new shorter look in an image she posted on her Twitter account.
Season ten of Two and a Half Men will premiere on Thursday, September 27 at 8.30pm on CBS.
Watch a season nine of Two and a Half Men below: