The star - who plays fun-loving teen Jake Harper on the show - has appeared in a testimonial for Forerunner Christian Church in which he asks viewers to stop watching Two and a Half Men.
"If you watch Two and a Half Men, please stop watching Two and a Half Men," Jones urges those watching the clip. "I'm on Two and a Half Men and I don't want to be on it."
Jones went on to explain he has come to object to the occasionally risqué humour on Two and a Half Men on religious grounds.
"Please stop watching it and filling your head with filth," he advised his fans.
"People say it's just entertainment. Do some research on the effects of television and your brain, and I promise you you'll have a decision to make when it comes to television, especially with what you watch."
The actor continued: "If I am doing any harm, I don't want to be here. I don't want to be contributing to the enemy's plan... You cannot be a true God-fearing person and be on a television show like that.
"I know I can't. I'm not okay with what I'm learning, what the Bible says and being on that television show."
[Pictured above: Angus T Jones and Miley Cyrus in 'Two and a Half Men']
Spokespeople for Two and a Half Men or its producers Warner Bros Television have not yet responded to Jones's comments.
The star's public rebuke of Two and a Half Men comes months after Jones signed a contract extension which sees him earn a reported $300,000 (£185,000) per show.
Former Two and a Half Men star Charlie Sheen famously sparked a media sensation in early 2011 by publicly slamming the show's co-creator Chuck Lorre.
The feud between the two grew so intense that Sheen eventually exited the CBS series, to be replaced by Ashton Kutcher.
Two and a Half Men airs Mondays at 8.30/7.30c on CBS.