The actor will helm the penultimate instalment of the show's upcoming final season, TV Guide reports.
It will be the second time that Connolly, who plays Eric Murphy in the HBO series, will have directed an episode of the show.
He previously stepped behind the camera for 'Porn Scenes from an Italian Restaurant', which aired last year.
Connolly has also expressed an interest in directing the potential Entourage movie.
The eighth and final season of Entourage will premiere on July 24 on HBO. The episode directed by Connolly is due to air on September 4.
Watch a teaser video for Entourage's final season below: