The project, which is set in a world inspired by Grimm's Fairy Tales, stars David Giuntoli as a detective called Nick who begins to see humans as magical beasts.
Deadline reports that Lee has now signed up to play one of Nick's colleagues.
Lee appeared as Bill Kim in Prison Break and played Tom in Persons Unknown. He also recently had a recurring role as Dr Chiles in No Ordinary Family.
Silas Weir Mitchell, Russell Hornsby, Bitsie Tulloch and Sasha Roiz have already been cast in Grimm.