The drama is set in a world inhabited by creatures inspired by Grimm's Fairy Tales and stars David Giuntoli as Nick, a detective who starts to see humans as magical beasts.
TV Line reports that Burton has now joined the cast and will play Nick's aunt, who is also thought to have some secrets.
Burton is described as a "special guest star" in the pilot but it is thought that her part could become a recurring character if the project is picked up.
Burton recently appeared in the movie 127 Hours and has had roles in shows including Grey's Anatomy, The Good Wife, Law & Order and Rescue Me.
Grimm also stars Reggie Lee, Silas Weir Mitchell, Russell Hornsby, Bitsie Tulloch and Sasha Roiz.