The creator of the Fox series revealed that the comedy is semi-autobiographical, saying that she wanted to explore her relationship with her guy friends.
"I started looking around my life and realised I had a lot of friends who were guys and I was thinking about why that was," Meriwether told the Los Angeles Times.
She went on to say that male friends provide a different sort of support from female friends.
"I wanted a girl sort of walking into a different world - a guy world," Meriwether said. "Guys help you in a different way than girls can. You get that tough love."
New Girl star Zooey Deschanel recently split from husband and Death Cab For Cutie singer Ben Gibbard.
The Fox comedy received a full season order from the network in September.
New Girl airs Tuesdays at 9pm on Fox.