The Single White Female actress will play the mother of Emily (Emily VanCamp) on the ABC drama, TVLine reports.
The character was presumed dead but was revealed to be alive in the show's first-season finale, 'Reckoning'.
Leigh is best known for her film credits, including roles in 1982's Fast Times at Ridgemont High and 1989's Last Exit to Brooklyn. She currently recurs as Jill Price-Grey on Showtime's Weeds.
English actor Barry Sloane has also been cast in the second season of Revenge - the former Hollyoaks star will portray a mysterious figure from Emily's past.
Revenge will return to ABC this fall. In the UK, the series airs on E4.
> Revenge exec on season two: 'Paying off our finale will be hard'
Watch Digital Spy's recent interview with Revenge star Emily VanCamp below: