Loosely based on Gideon Raff's Israeli television series Prisoners of War, it centres on a US soldier (Lewis) taken prisoner in Iraq in 2003.
Danes plays CIA officer Carrie Anderson, who is convinced that the soldiers' return is set up and that the new national hero is working with Al-Qaeda to launch an attack on US soil.
Mandy Patinkin (Criminal Minds) and David Harewood (Blood Diamond) will also star.
Channel 4's chief creative officer Jay Hunt described Homeland as a "compelling contemporary thriller".
The broadcaster also revealed today that it has picked up the rights to comedy series Napoleon Dynamite, Zooey Deschanel's New Girl, animation Allen Gregory and James Van Der Beek's Apartment 23.
Watch a trailer for Homeland below: