The Prime Suspect actress had been upgraded to a series regular for the drama's upcoming second season.
However, despite only appearing at the very end of the first season so far, Bello has left the drama, reports TV Line.
Fox and 20th Century Television representatives have yet to give an official reason behind Bello's exit.
Bello's departure is said to have been a mutual decision between the actress and Touch producers.
She plays a character named Lucy, whose daughter shares the same gift as lead star Kiefer Sutherland's son Jake, with both families meeting at the very end of the first season.
It is not currently clear how Lucy will be written out of the drama.
Touch returns with a two-hour special episode on Friday, February 8, after being pushed back from October 26.