The actor will play pawnbroker Glen Fogle in the FX drama's third season, according to TV Guide.
Described as a 'modern-day Fagin', Fogle deals in stolen goods and pays his hired thieves with painkillers.
Vince recently played Otis on AMC's The Walking Dead and has previously appeared on Deadwood, House and CSI.
His film credits include roles in 2000's Nurse Betty, 2003's Identity and 2005's Constantine.
Carla Gugino will also star in the third season of Justified, appearing alongside Timothy Olyphant and new cast additions Neal McDonough and Mykelti Williamson.
The new season entered production last month and will premiere on FX in early 2012.
> Justified star to return for season three
Watch a promo for Justified below: