The supernatural drama, which is based on a series of books by Gabriella Pierce, focuses on a young couple who begin managing one of the oldest apartment buildings in New York.
However, they soon start to experience a series of spooky events.
Taylor has now landed the role of the wife in the drama, The Hollywood Reporter says.
She will star opposite Brothers & Sisters actor Dave Annable, who has signed up to play the husband.
Taylor recently starred in ABC's short-lived reboot of Charlie's Angels. Her previous credits include roles in Grey's Anatomy and the movie Transformers.
Lost star Terry O'Quinn has also signed up for a part in 666 Park Avenue and will play the owner of the haunted building.