The actor - who played John Locke - told Vulture that the hit ABC drama was a "one-off phenomenon".
"I don't think anything's going to be Lost," he said. "On the other hand, you know, things can take off. I've seen things that I didn't think deserved the attention they got, get it. And the other way around."
O'Quinn - who will next be seen in new ABC drama 666 Park Avenue - admitted that the success of Lost made it difficult to pick his next project.
"It made it very challenging for whatever I was going to do next," he explained. "It would be putting too much of a burden on 666 or anything to have those kinds of expectations. So, I don't have expectations at all. Be prepared for the worst and hope for the best."
The 60-year-old star added that his villainous 666 character Gavin Doran has "a lot of potential" to develop.
"In the pilot, he's kind of one-note," said O'Quinn. "But I think if the thing goes at all, he's gonna have to develop some layers.
"It's fun to play bad guys. They have better secrets, they hold a lot more things closer to the chest."
666 Park Avenue premieres on ABC in the US on September 30, 2012.
> Terry O'Quinn's '666 Park Avenue' adds Enrique Murciano
> Terry O'Quinn's '666 Park Avenue' adds Mike Doyle, Aubrey Dollar
Watch the trailer for 666 Park Avenue below: