The 28-year-old actress will recur on the ABC horror drama, which stars Lost's Terry O'Quinn, reports Deadline.
© WENN / FayesVision
© ABC
Thompson will play Laurel Harris, a media consultant who meets Henry Martin (Dave Annable) and causes problems in his relationship with girlfriend Jane (Rachael Taylor).
Her past credits include roles on Grey's Anatomy, Heroes and ABC's short-lived cop drama Detroit 1-8-7. She will also star in BBC America's forthcoming series Copper.
666 Park Avenue has also cast Enrique Murciano (Without a Trace), Mike Doyle (Law & Order: SVU), Aubrey Dollar (Weeds) and Mili Avital (Damages) in supporting roles.
The series debuts in the US on Sunday, September 30 at 10/9c and will air on ITV2 in the UK.
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Watch the trailer for 666 Park Avenue below:
