The English actor plays serial killer Joe Carroll on the Fox drama, which has attracted some criticism for airing violent scenes on network television.
"I'm surprised that in a society, in a culture that's been watching violence on film, television, and stage for two and a half thousand years, anyone brings it up anymore," Purefoy told Vulture. "The very idea - it's just preposterous, to tell you the truth."
The 48-year-old also insisted that "violence on television, film, or in video games has [no] effect whatsoever" on an audience.
"[Violence on TV] is a smokescreen, an excuse," Purefoy insisted. "The situation is much more complex than people watching violence in entertainment.
"These programmes are seen all over the world and it's only in [the United States] that these kind of things are happening with such alarming regularity."
However, the actor did submit that airing on network television limits how much on-screen bloodshed The Following can incorporate.
"It's not cable, it's on network," he said. "You're not going to see a scalpel going in to somebody's eye, not on network. I think we cut away just before that."
The Following airs on Mondays on Fox and continues on Tuesday nights at 10pm on Sky Atlantic in the UK.
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Watch James Purefoy talk The Following with Digital Spy below: