The season five cliffhanger saw James Denton's character Mike Delfino get married, but viewers were unaware of the identity of his bride.
The opening sequence of season six later revealed the bride to be Teri Hatcher's Susan Mayer, despite Mike previously being engaged to Katherine (Delany).
"[Marc Cherry] called me a week before we started shooting and said, 'Oh, I realise I should tell you because I told Teri already. You're not marrying Mike'.
"And I was in shock. I really thought it was me! Then he said, 'And you're going to have a nervous breakdown'. And I said, 'Thank you. Much better!'"
Desperate Housewives continues Sundays at 9pm on ABC in the US and Wednesdays at 10pm on Channel 4 in the UK.
> Click here to read our full interview with Dana