The actress played Edie Britt since the show's inception in 2004 but was killed off during season five.
Speaking exclusively to Digital Spy, Huffman said: "I miss Nicolette - she was cool.
"She's just a really wonderful woman and a cool chick and I think what she brought to the show was a certain vinegar, a certain little spice. They're going to have to find that kind of thing elsewhere in a different form."
Drea De Matteo joined the cast in season six as the Edie-esque head of a new family called the Bolens, but claimed that she is not replacing Sheridan's character.
Desperate Housewives continues Sundays at 9pm on ABC in the US and Wednesdays at 10pm on Channel 4 in the UK.
> Click here to read our full interview with Felicity