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Rex Features
The Torchwood star told Digital Spy that he will be playing a villain who changes the lives of "every one of the women" on Wisteria Lane.
"I haven't met any of them - the only person I know is [creator] Marc Cherry. The reason that I am going over to do Desperate Housewives is because Marc is a fan of Torchwood and Marc loved Captain Jack and he said, 'I'd love to bring you out here to do something'.
"I'm doing five episodes and I'm gonna be a villain. I will be involved in the mystery storyline that they're doing at the moment with [Drea de Matteo]. I've been told by Marc that I will affect every one of the women in some way."
He added that he "can't wait" to read the scripts and hopes that Doctor Who and Torchwood fans will tune in.
Desperate Housewives continues Sundays at 9pm on ABC in the US and Wednesdays at 10pm on Channel 4 in the UK.
> Click here to watch our full interview with John Barrowman
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