Speaking to TV Guide, Bob Daily explained that Paul (Mark Moses) will be shot by an unknown attacker.
Daily suggested that there are a number of possible suspects, saying: "We very carefully planted guns in the episode."
He explained that Bree (Marcia Cross), who is "the most avid markswoman on the Lane", will be furious about Paul's attempts to found a halfway house on the street.
He added that Lee (Kevin Rahm) will be shunned by Wisteria Lane's residents after selling Paul so many houses, saying: " As Lee and Bob pack to leave the Lane, we see Lee's packed a gun."
Daily also hinted that Paul's wife Beth (Emily Bergl) has already been seen with a gun and reminded viewers that Felicia (Harriet Sansom Harris) vowed in the season premiere that Paul would be dead within six months.
He refused to reveal any further details but promised that the shooter "is someone who has been a regular character on the show".
The next episode of Desperate Housewives airs on Sunday at 9/8c on ABC. The show will then return for new instalments early next year.