Sources claim that ABC will officially announce the show's axing at the Television Critics Association summer press tour on Sunday.
The comedy-drama's stars Teri Hatcher, Felicity Huffman, Marcia Cross, and Eva Longoria have allegedly already been informed and are described as being "shocked and saddened" by the development, TV Line reports.
Rumours that Desperate Housewives would end next year first circulated in July, when an ABC insider claimed that the commissioning of a ninth season would be "dependent on the ratings".
Desperate Housewives creator Marc Cherry previously revealed his hope that the show would continue into 2013, declaring: "I think that's what everyone would be happy with. I think nine years would be a really good run."
The show was renewed for an eighth season back in May and will return to US screens on September 25.
Watch the opening of the first ever episode of Desperate Housewives below: