Mary Alice is the narrator on the ABC series and was killed off in the first ever episode. However, Strong has reappeared in numerous flashback sequences during the show's past seven seasons.
Following the announcement that creator Marc Cherry is bringing Desperate Housewives to a close at the end of the upcoming eighth run, Strong told Deadline that she expects to figure more heavily in the finale plotlines.
"Marc has always said that he intended for Mary Alice to have a bigger presence in the final season," she said.
Co-star Felicity Huffman, who plays Lynette Scavo, added that she expects some big twists to the Mary Alice storyline, commenting: "It will have to be a new well, you can't go back to the same well twice... You don't want to jump the shark in your final season."
The eighth and final season of Desperate Housewives premieres on September 25.
> Brenda Strong promises Desperate Housewives flashbacks
> Marcia Cross: 'Desperate Housewives end is bittersweet'
Watch Digital Spy's interview with Felicity Huffman about series eight below: