The promo clip contains the tagline 'Kiss Them Goodbye', and hints that the episode will contain a shocking character death.
The drama - which is currently in its final season - was recently rumoured to contain a "major" death in a March episode.
Desperate Housewives continues with 'You Take for Granted' at 9/8c on Sunday (March 11) on ABC.
> Eva Longoria rules out Desperate Housewives movie
Watch the teaser from ABC below: