The Desperate Housewives star confessed that the trial, in which Sheridan sued Cherry and ABC for wrongful termination, has put a dampener on the series' final season.
"I was surprised that there was even a trial and it went that far," Longoria told Katie Couric on Good Morning America.
"I love Nicollette, and I love Marc Cherry, and I love our work environment. It's a stain on our legacy as a hit show. It was just unfortunate, the whole thing."
Sheridan's case against ABC was declared a mistrial in mid-March after the jury became deadlocked and unable to reach a verdict.
However, Cherry was cleared after a judge dropped the battery charges against the Desperate Housewives showrunner.
Sheridan had claimed that he hit her on the head, though he insisted that it was purely a tap for artistic direction.