The actress was only seen in four episodes of the Netflix show's second run, despite her character still being involved in a major story arc with Piper Chapman (Taylor Schilling).
Prepon recently explained to Us Weekly that scheduling was to blame for her absence last season.
"It sucked because [show creator] Jenji Kohan and I wanted me to be in it more, but with the schedule, it didn't happen. I was so bummed," she said.
The actress also confirmed previous reports that she will be back full-time for Orange Is the New Black's third season.
"I handled [the scheduling problems], so I'm in every [episode] in season three. It is so good," she teased.
Orange Is the New Black returns to Netflix next year.
Gallery: Orange Is the New Black premiere