Rumours about a possible cameo from Murray and his co-star Hilarie Burton have been circulating since the duo left One Tree Hill after the sixth season.
Murray has now fuelled the speculation further by suggesting that he would like to reprise his role as Lucas for the ninth season of the show, which is expected to be the last.
However, he clarified that he has no idea whether it will be possible for him to return.
Murray told E! Online. "I honestly haven't heard a word. I haven't heard anything. I know how much the fans want it and for the fans I think I would definitely do that. Absolutely."
He continued: "I don't know where they're taking the storyline. It's all up in the air. I'm supposed to start shooting another movie in September, so if everything works out, we'll give one for the fans."
Paul Johansson and Tyler Hilton have already signed up to reprise their roles in the ninth season of One Tree Hill, which will air on The CW in midseason.
Watch a clip of Chad Michael Murray in One Tree Hill below: