Devine has starred in the show since the first season as Adele Webber, Chief Webber's wife.
According to E! Online, she has now signed up to reprise her role in an episode due to air in February.
Adele will reportedly arrive at Seattle Grace Mercy West because she is ill and needs medical attention, but further details of the storyline have not yet been revealed.
Grey's Anatomy airs on Thursdays at 9/8c on ABC in the US and on Wednesdays at 10pm on Living in the UK.