In this week's episode of the show the actress will reprise her role as Chief Webber's wife Adele, who arrives at the hospital needing medical attention.
Speaking to Entertainment Weekly, Devine joked that she hopes Adele's ailment is not too serious.
"I'm a little scared myself!" she said. "I know she keeps falling and that she's blaming it on her shoes. They don't know what it is, I think. I have a couple more episodes [to film], so I think we'll be finding out in the next couple of episodes."
Devine added that Adele and her husband will be "at the happiest point they've ever been in their lives" and "very much in love", but hinted that Adele does not get on with everyone so well.
"I have a couple of great scenes with Bailey [Chandra Wilson]," she teased. "Bailey and I are always butting heads because those are two powerful women. So they send Bailey in to examine me, and my God, we get into it. She still has her spunk, I would say."
Grey's Anatomy airs on Thursdays at 9/8c on ABC.