McKidd explained that the duo will start to spend time together because of their marriage problems.
Derek (Patrick Dempsey) is arguing with Meredith (Ellen Pompeo) after she tampered with his Alzheimer's trial, while Owen and Cristina (Sandra Oh) are fighting over whether or not to have a baby.
"Derek and Owen are dealing with the twisted sisters - Meredith and Cristina - who are very connected and very similar in a way," McKidd told TV Guide. "So they try to get away from the women a bit more."
McKidd added: "Owen starts helping Derek build his house, so they bond over that and the manliness of being outdoors and carrying wheelbarrows full of rocks. It's a way for them to decompress from all the pressure."
Grey's Anatomy will return for its new season on September 22 on ABC.
> 'Grey's Anatomy' Kevin McKidd teases Owen twist
Watch a trailer for the new season of Grey's Anatomy below: