Last season, it emerged that Adele is ill and may have Alzheimer's disease. Meredith (Ellen Pompeo) later tampered with Derek's clinical trial to ensure Adele got treatment.
Kevin McKidd recently revealed that he will be promoted to Chief as Webber (James Pickens Jr) steps down to spend more time with Adele.
However, Devine has now hinted that Adele may not be happy with Webber's decision.
"A lot of times wives complain about stuff, like, 'My husband watches too much baseball or he's too attached to this, that, and the other'," she told TV Guide. "But in a way, you're really glad that the man has passions the same way we do.
"Adele might say that she doesn't want him to work but that's all she's ever loved about him. She may be unhappy for him until he adjusts to his new life."
Devine added that she is hoping for a happy ending for Adele, saying: "You hope that there's some kind of recovery for her or that there's a better way of life or state of longevity of life, where she's clear on things. You're hoping that she doesn't even have it."
Grey's Anatomy will return with its new season on September 22 on ABC.
> 'Grey's Anatomy' star: 'Derek, Owen will bond'
> Read more Grey's Anatomy coverage
Watch the trailer for the new season of Grey's Anatomy below: