The show's executive producer Shonda Rhimes revealed the news on her Twitter page after working on the instalment.
"Table read for the all boys episode of Grey's Anatomy was hilarious!" she said.
Rhimes also responded to a fan who suggested a subsequent "all girls" instalment, joking: "Um, every episode of [Grey's Anatomy] is essentially an all girls episode."
The episode to which Rhimes was referring will feature voiceovers from Owen (Kevin McKidd), Derek (Patrick Dempsey), Alex (Justin Chambers) and some of the other male characters, Entertainment Weekly reports.
The female stars of Grey's Anatomy are still expected to appear in the instalment, which focuses on a disaster at a convention similar to Comic-Con.
Grey's Anatomy will return with a two-hour season premiere on September 22 on ABC.
> 'Grey's Anatomy' star: 'Derek, Owen will bond'
> Read more Grey's Anatomy coverage
Watch a trailer for the new season of Grey's Anatomy below: