The Barbershop actor will reprise his role as Dr. Ben Warren in the show's eighth season, according to TV Line.
Warren last appeared in the medical drama's seventh season premiere, in which his character was rejected by girlfriend Miranda Bailey (Chandra Wilson).
His return for multiple episodes will reportedly complicate Bailey's new romance with Nurse Eli (Daniel Sunjata).
George has previously appeared in episodes of Castle, Desperate Housewives and CSI: Miami. He also played Dr. Otis Cole in ABC's short-lived medical drama Off The Map, from Grey's Anatomy creator Shonda Rhimes.
Fame star Debbie Allen will also appear in the new season of Grey's Anatomy, which will feature an episode focusing on the show's male characters.
Grey's Anatomy will return with a two-hour season premiere on September 22 on ABC. George's return is expected to air in either late October or early November.
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Watch a trailer for the new season of Grey's Anatomy below: