Grey's Anatomy powered ABC to a comfortable win in the US on Sunday, early figures indicate.

The medical drama had 21.1 million viewers at 10pm to rank as the night's most-watched programme overall, easily beating CBS original Time Bomb (8 million) and NBC's Crossing Jordan (10.1 million).

FOX's animation/comedy lineup delivered the goods in the 18-49 demo, led by The Simpsons (8.8 million) and Family Guy (7.3 million). At 9.30pm, Free Ride improved slightly on last week's time period premiere to average 5.4 million.

Elsewhere, West Wing lifted to 8 million for NBC at 8, its best overnights score since last November.