Spears recently filmed a cameo for the programme which will air in the episode based on her music.
In an interview with Access Hollywood, Murphy was asked whether Spears will appear in any future episodes.
"Probably, yeah," he replied. "Probably."
Murphy also revealed that he is surprised about the show's success, saying: "I never thought it would work at all. I thought it was very good, and I thought the cast was great, but I thought the idea was kind of particular. I'm shocked."
> 'Glee' creator praises Britney Spears