Future episodes of the Fox drama will follow the students at McKinley High, as well as the adventures of Rachel (Lea Michele) and Kurt (Chris Colfer) in New York.
Murphy confirmed to TVLine that the new season will shoot on location, stating: "We're coming to New York. That was one of the fun reasons to do [the storyline]."
He added: "Nothing is in stone, because we're still budgeting, but I would love to come once every five weeks and shoot a lot of scenes there. We are 100 percent doing that - we're not going to do it all on a soundstage."
The new season of Glee is expected to produce alternate episodes, switching between McKinley High and New York each week.
Murphy previously confirmed that all of the show's regular cast members will remain for season four.
"It doesn't mean everyone will be doing 22 episodes, but everyone wants to stay in our family and our world," he explained. "I wanted to make sure those actors know that if they want to have a home, they have a home."
Glee will return to Fox in the fall, airing in a new Thursday night slot at 9/8c. In the UK, the show continues Thursdays at 8pm on Sky1.
> Glee: Gloria Estefan wants season four return
> Matthew Morrison on Glee season finale: 'It was hard saying goodbye'
Watch a promo for the Glee season finale below: