The network has chosen to launch a number of new series and seasons several days earlier than the traditional late September premiere week, potentially getting a jump on rivals NBC and CBS.
The new-look X Factor USA - featuring returning judges Simon Cowell and Demi Lovato with new faces Kelly Rowland and Paulina Rubio - kicks off the new slate of programming on Wednesday, September 11. The second part of its premiere will air the following evening.
Tom Mison stars as Ichabod Crane in the Washington Irving adaptation Sleepy Hollow, which begins on Monday, September 16, following the first episode of the ninth season of Bones.
Seth MacFarlane's Dads and Andy Samberg's Brooklyn Nine-Nine get under way on Tuesday, September 17, alongside returning favourites New Girl and The Mindy Project.
Glee season five commences on Thursday, September 19, while Gordon Ramsay's MasterChef Junior arrives the following evening.
The animated comedy block of The Simpsons, Bob's Burgers, Family Guy and American Dad airs from Sunday, September 29.
JJ Abrams's new action sci-fi Almost Human will debut later in the fall, taking over Bones' Monday night slot on November 4 when the crime procedural moves to Fridays.
Finally, Raising Hope season four and Kevin Biegel's new comedy Enlisted will air from Friday, November 8.
Check out the full lineup below:
Wednesday, Sept. 11
8-9pm THE X FACTOR (Season Premiere, Part One)
9-10pm MASTERCHEF (Season Finale)
Thursday, Sept. 12
8-10pm THE X FACTOR (Season Premiere, Part Two)
Monday, Sept. 16
8-9pm BONES (Season Premiere)
9-10pm SLEEPY HOLLOW (Series Premiere)
Tuesday, Sept. 17
8-8.30pm DADS (Series Premiere)
8.30-9pm BROOKLYN NINE-NINE (Series Premiere)
9-9.30pm NEW GIRL (Season Premiere)
9.30-10pm THE MINDY PROJECT (Season Premiere)
Wednesday, Sept. 18
8-10pm THE X FACTOR (All-New)
Thursday, Sept. 19
8-9pm THE X FACTOR (All-New)
9-10pm GLEE (Season Premiere)
Friday, Sept. 27
8-9pm MASTERCHEF JUNIOR (Series Premiere)
9-10pm SLEEPY HOLLOW (Encore)
Sunday, Sept. 29
8-8.30pm THE SIMPSONS (Season Premiere)
8.30-9pm BOB'S BURGERS (Season Premiere)
9-9.30pm FAMILY GUY (Season Premiere)
9.30-10pm AMERICAN DAD (Season Premiere)
Monday, Nov. 4
8-9pm ALMOST HUMAN (Series Premiere)
9-10pm SLEEPY HOLLOW (All-New)
Friday, Nov. 8
8-9pm BONES (Time Period Premiere)
9-9.30pm RAISING HOPE (Season Premiere)
9.30-10pm ENLISTED (Series Premiere)
Fox 2013/14 new shows in pictures: