Entertainment Weekly says that Wilde, who plays Thirteen on the show, has made the decision so that she can star in new movie Cowboys & Aliens.
Production on the film, directed by Jon Favreau, is expected to clash with House for at least two months.
House's executive producer Katie Jacobs explained: "Olivia will be there at the very beginning of the season and then she will not be there for a period of time. She had this opportunity and she was really excited about it. We're very proud of her and very happy for her."
Jacobs added that the storylines on House have been planned to fit in with Wilde's schedule.
"The two things - the dates she was going to be away and the storyline [we wanted to tell] - worked out," she explained. "When the story unfolds, it will [all make] sense."
The season finale of House airs in the UK on Sunday at 10pm on Sky1.