Tamblyn will star in the series as medical student Martha M. Masters, who arrives when Cuddy (Lisa Edelstein) urges House (Hugh Laurie) to hire a woman.
"Considering how horrific House is to doctors, just imagine him being your first mentor," Jacobs told TV Guide. "Her first challenge is - can she stay on House's team?"
However, Jacobs explained that she does not want Martha to begin a relationship too quickly and Jesse Spencer, who plays Chase, revealed that his character will not have a romance with her.
"She's too uptight for him and too much like what [his ex-wife] Cameron used to be," he said. "She comes in all wide-eyed and moralistic, and Chase loves watching House devour her. He takes her to the cleaners and it's hilarious."
House continues on Mondays at 8/7c on Fox. Tamblyn is expected to make her debut in the sixth episode of the season.