The actress, who plays Thirteen, took some time off from the show to film the movies Cowboys & Aliens and The Change-Up.
However, she told Entertainment Weekly: "I am coming back to House. This season, as a matter of fact. It is a done deal."
Wilde also promised that her absence from the show will be explained when she returns.
"They have it all worked out and the viewers will find out where she went and why she left," Wilde said. "I think it is an interesting progression for her. Thirteen has been through a lot so it has to be escalated. She has Huntington's. She had a brain tumour and went blind. She had a bad breakup. She's sexually ambiguous. She had problems with drugs.
"I thought, 'What else can [creator] David Shore possibly come up with?'. They had to take it to a whole new level. They are really taking some big risks this year, which is exciting."
House continues on Mondays at 8/7c on Fox.