The actress recently joined the cast of the Fox medical drama as the socially awkward Martha Masters.
She told the Boston Herald: "I thought, 'I don't want do a medical show, that doesn't sound very fun to me'. I started asking my friends [about it] and they all went, 'Are you an idiot? Have you ever seen it?' I felt stupid for ever thinking that. I rented a bunch of the seasons... and I was really blown away."
She explained that the character is partly based on a real-life medical student, also called Martha Masters.
"They made her sign a release saying she wouldn't sue Fox," revealed Tamblyn. "I'm not saying anything out of turn or mean about her, but she's incredibly brilliant and sometimes she can be very socially awkward."
Tamblyn previously dismissed rumours of a romantic link between her character and Chase (Jesse Spencer).
House continues on Mondays at 8/7c on Fox.